Ketamine-assisted psychotherapy (KAP) is a form of psychotherapy that incorporates the use of ketamine as a catalyst within the therapy process. Ketamine is administered to temporarily induce a state that lasts 30 minutes up to 2 hours, during which patients may experience reduced negative thought patterns, diminished hypervigilance, and increased openness to emotions. This state can make it easier for patients to engage with and process topics during therapy that are typically too distressing to confront. The neurobiological effects of ketamine itself can quickly alleviate symptoms of depression. When combined with psychotherapy, these effects may not only be enhanced but also contribute to greater neuroplasticity, the brain's ability to adapt and reorganize. This synergistic combination aims to maximize the therapeutic benefits and extend the duration of positive outcomes.

Ketamine can be delivered through various methods, such as intravenous (IV) infusion, intramuscular injection, nasal spray, or sublingual (under the tongue) tablets. In my clinical practice, I provide patients with sublingual tablets to be taken during their KAP sessions. Before starting KAP, I perform comprehensive medical-psychosocial evaluations to determine if patients are suitable candidates for this treatment. After confirming their eligibility, I work in tandem with therapists trained in KAP. These therapists are responsible for conducting the psychotherapy aspect of the treatment.